Translational Control of Aldosterone Production in Aldosterone-Producing Adenomas
نویسندگان
چکیده
منابع مشابه
Aldosterone-Producing Adenomas
Unilateral primary aldosteronism (PA) is a common surgically curable cause of secondary hypertension. Adrenal glands removed for unilateral PA display histological heterogeneity. Recently, gain-of-function somatic mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 have been found in 50% to 80% of aldosterone-producing adenomas (APAs). These gain-of-function mutations provide plausible mech...
متن کامل19-Nor-deoxycorticosterone production from aldosterone-producing adenomas.
19-Nor-deoxycorticosterone (19-nor-DOC), a hypertensinogenic mineralocorticoid, equipotent with aldosterone and independent of the renin-angiotensin system, is synthesized in the kidney and excreted in excess in the urine of patients with aldosterone-producing adenomas. This current study evaluated the adrenal and renal venous levels of aldosterone and 19-nor-DOC after adrenal and renal venous ...
متن کاملLocalization of the endothelin system in aldosterone-producing adenomas.
Endothelin-1 (ET-1) could play a role in the regulation of aldosterone secretion of the human adrenal gland. The presence of the endothelin-converting enzyme 1 (ECE-1) and ET-1 suggests that there is a local ET system in the adrenal cortex, but the in situ synthesis of ET-1 remains to be confirmed. The cellular distribution of the whole ET system was evaluated in 20 cases of aldosterone-produci...
متن کاملActivating mutations in CTNNB1 in aldosterone producing adenomas.
Primary aldosteronism (PA) is the most common cause of secondary hypertension with a prevalence of 5-10% in unreferred hypertensive patients. Aldosterone producing adenomas (APAs) constitute a large proportion of PA cases and represent a surgically correctable form of the disease. The WNT signaling pathway is activated in APAs. In other tumors, a frequent cause of aberrant WNT signaling is muta...
متن کاملGenetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas
Åkerström, T. 2016. Genetic Alterations and Molecular Signatures in Aldosterone Producing Adenomas. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1197. 49 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9517-6. Primary Aldosteronism (PA) is caused by autonomous overproduction of aldosterone. Aldosterone is necessary for fluid and ion homeosta...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2020
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.119.14196